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Researchers Gualtieri and Hicks posit that this may occur because of a maternal immunization effect. A mother carrying her first son has very little exposure to the proteins he is making because of the placental barrier.
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Human brains are remarkably alike. They all contain cerebral hemispheres, a corpus collosum , white matter, and other structures that mediate behavior, thought, and mood. Subtle architectural changes, however, can have a profound change in these capacities. Research suggests that the default genetic blueprint of a human brain is a right-handed female. At the seventh week of gestation, the male fetus begins to secrete testosterone, and this lateralizes the brain.
Among the changes from female to male architecture is the pruning of the corpus collosum. Savants — people who often have remarkable abilities with memory, math and music — frequently have a significantly smaller corpa collosa. Autism is one of the most heritable mental disorders.
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People exhibiting alexithymia have a difficult time speaking about, or even being aware, of their feelings. See the skin and hair sections below. Feelings are often seen as bothersome or useless. People with these traits are often depicted by family and friends as cold, distant, and nonassertive. Research suggests that alexithymia often acts as a trigger for many medical and psychiatric disorders.
This also contributes to marriage and family problems. Spouses and family will often complain that the person is cold, aloof, and non-caring. This state of being seems to be hardwired early on in brain development.
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Researcher and author Alan Schore believes that attachment makes possible the emergence of affect regulation, located in the right orbital prefrontal area, but others believe the predisposition for this is hard wired. Von Economo neurons discovered by researcher Constantin von Economo thus far have only been found in humans, the great apes, humpback whales, fin whales, killer whales, sperm whales, and African and Asian elephants.
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From to , the California State Department of Developmental Services reported a percent increase in autistic disorders, while the state population grew only 19 percent. The increase did include cases of high-functioning autism or Asperger's. Most humans are right-hand dominant, but there are a growing number who are not right-handed.
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The sneezing and runny nose you have makes you miserable. The aches and pains and lethargy make you want to go to bed and sleep for a week. You don't feel like doing anything. Getting up to pay the bills seems like an overwhelming task, and you can't even focus on the book you took to bed with you.
All you want to do is sleep. The above is a good description of the common cold, but if you take away the sneezing and runny nose, it also looks a lot like depression. The immune system is the part of the body that that fights infection.
When the body has a cold, the immune system goes to work by attacking the virus with an array of special cells, proteins, and organs. Immune system cells are white blood cells called leukocytes. These cells are manufactured and stored in many sites in the body, especially in the thymus, spleen, and bone marrow.
In addition, throughout the body are groups of cells called lymph nodes that house leukocytes. Leukocytes constantly circulate through the blood vessels, but they also travel through the body by way of the lymphatic system. Researchers have suspected for many years that infections can lead to mental illness. In fact, in an editorial entitled Is Insanity Due to a Microbe? Syphilis, once considered to be a common mental illness, was eventually found to be caused by a virus.
There was a lull in research during the era of psychoanalysis, but in , psychiatrist and researcher E. Fuller Torrey at the Stanley Medical Research Institute in Chevy Chase published a series of articles suggesting that microbial infections could cause mental illness.
In the last decades, it has become clear that microbes and pathogens are the cause of many mental illnesses. It now appears that schizophrenia, autism, bipolar disorder, and other mental problems are linked to various infections, including fungal, viral, and parasitic infections.
These infections can attack the nervous system during pregnancy, childhood, or later life. While some infections directly affect the brain, others trigger immune reactions that interfere with brain development or perhaps even attack our own brain cells in an autoimmune mistake. More than studies have suggested that schizophrenia occurs between five to eight percent more frequently than average in children born in the winter or spring.
Viruses are most prevalent in the cold winter months. In , researchers at Columbia University suggested that one-fifth of schizophrenias are caused by prenatal infections. It has also known that streptococcus can, if left untreated, lead to serious psychiatric problems. The mapping of the human genome has revealed connections between genes, microbes, the immune system, and mental illness.
An alteration of genetic markers in a particular population has also been shown to provide resistance to specific diseases. For example, schizophrenia has been shown to have a strong inverse correlation with rheumatoid arthritis, such that one disorder protects against the other. The burgeoning field of research linking the immune system and mental health is called psychoneuroimmunology. The immune system and the brain are alike in two fundamental ways.
Both have the capability to store new information in a form of memory and both are able to recall that information in response to an appropriate stimulus. Both systems have an intricate network of synaptic connections and also share a number of messenger molecules, such as cytokines and chemical mediators.
There is only one type of immune cell inside the brain — microglia. Microglia cells are similar to immune cells found in the body, called macrophages. Microglia do not mount much of an immune response in the brain. In fact, in some instances they made even be harmful to brain cells. Jerome Posner has found that a tumor — anywhere in the body — can lead to degeneration of specific brain regions by means of molecular mimicry.
Antigens from the tumor cells induce antibodies that trigger immune responses both in the tumor and in the brain. This can lead to an immune attack on the brain resulting in neural damage.
For example, inner uterine cancer may cause damage to the cerebellum. The clumsiness that is caused by this damage may appear years before the cancer is diagnosed. Posner found that certain types of tumor cells expressed the same target protein that was the antigen under attack in neurons.
The term paraneoplastic syndrome is a disorder or set of symptoms that is triggered by cancer in the body, but is not due to the local presence of cancer cells. Patients with paraneoplastic psychological disorders have a reactive immune response to the tumor. A similar autoimmune attack against the brain is damage to the myelin sheath, found in multiple sclerosis.
In animals, this molecule is called the major histo-compatibility complex, commonly cited as MHC, a cluster of genes located on chromosome 6 concerned with antigen production and critical to the success of transplantation. When a pathogen is noticed by the immune system, molecules take a fragment of the pathogen's peptide, which is then displayed to a certain type of immune cell, so it can identify the pathogen and attack it.
In the developing brain, the same molecule appears to be essential for one brain cell to determine which other brain cell to which to connect. This suggests the same family of genes may be involved in a recognition process of cells in the immune system and the nervous system.
Cytokines a word originating from the Greek words cyto -, meaning cell, and kinos , meaning movement are a number of substances that are secreted by cells of the immune system that carry signals locally between cells and have an effect on the other cells. The immune system is a messenger that alerts the brain to infection or injury by releasing proteins called proinflammatory cytokines.
The brain releases its own cytokines that signal the central nervous system to help the body adapt by reducing energy output.
Increases in certain cytokines often interluekin-1, interluekin-6, and tumor necrosis factor alpha induce fatigue, anorexia, weight loss, sleep disturbance, loss of libido, memory problems, anhedonia, and irritability.
These behavioral changes are referred to as sickness behavior. It has been observed that couples and family members with high levels of cytokines tend to fight more often. In autoimmune disorders, the immune system mistakenly attacks the body's healthy organs and tissues as though they were foreign invaders.
In addition, the increase of intestinal permeability seen in these disorders is also seen not only in healthy relatives, but also in spouses of these patients, suggesting these problems may be transferred by pathogens. At the same time, the number of people with mental disorders has also risen dramatically.
A significant number of these maladies are thought to be caused by immune dysregulation. Epidemiologic studies suggest that the overuse of antibiotics is connected to a reduction in the incidence of infectious diseases throughout the lifespan, which results in a compromised immune system. In the last few years, it has become evident that the immune system can attack and disorder the brain.
In fact, the bulk of recent research of the cause of mental illness has shifted from neurotransmitters to immune dysfunctions. Many of these disorders respond to therapies that target autoimmune response. Rheumatoid arthritis is a chronic, progressive autoimmune disease. The disease causes and joint destruction, disability, and significant pain. It is estimated to affect about one percent of adults worldwide, increases in prevalence with age, and affects more women than men.
The magnitude of the severe long-term economic consequences of the malady has been underestimated in the past. Most people with the disease require continuous treatment to retard or stop its progression and to control disease flare-ups.
Many will require surgery, such as total hip or knee replacements. In addition to these direct costs, work disability leads to reduced productivity and early retirement, and as a result, substantial indirect costs. The disease commonly results in premature mortality, resulting in a mean reduction in life expectancy somewhere between 5 to 10 years.
Those suffering with arthritis often experience loss of self-esteem, fatigue, mental distress, and depression. Medical symptoms of Lupus. Lupus is a chronic disease that often manifests as muscle pain, joint pain, and inflammation. The abnormal immune response may also involve attacks on the kidneys and other organs. Ninety percent of cases occur in women of childbearing age. The medical term for lupus is systemic lupus erythematosus, or SLE. Erythema is a redness of the skin caused by dilatation and congestion of the capillaries, which is often a sign of inflammation or infection.
The word Lupus means wolf and , interestingly, Lupus is also found in dogs. Some researchers believe that Lupus patients have infected the dogs. The age of onset in Lupus is generally in the mid-to-late 20s, but African-Americans tend to get a more severe variant of the disease with an earlier onset. The disorder is believed to be genetic. It often appears in certain families. When one of two identical twins has Lupus, there is an increased probability that the other twin will also develop the disease.
Although Lupus can develop in people with no family history of the malady, there is often a presence of other autoimmune diseases in family members. The prevalence of Lupus is significantly higher in females than in males. It is the most common cause of stroke in young women. While it is posited sex-linked genes may contribute to this, other studies suggest sex hormones, especially estrogen and prolactin, are a factor.
Despite the evidence of genetic vulnerability to date, no gene or group of genes has been proven to cause the disorder. Lupus is usually triggered by environmental events, exposure to sunlight being one well-known trigger. It may cause mood and anxiety disorders, particularly major depression and generalized anxiety disorder.
The diagnosis is made by a variety of clinical examinations and blood tests. Sixty years ago, SLE was an uncommon disorder, affecting an estimated three to four individuals per , Today, the estimated prevalence of this disease has increased by about four to fifteen times. Lupus often presents with severe fatigue, painful joint swelling, and persistent skin rashes, but it can affect any organ system in the body including kidney disease, blood clotting, and central nervous system diseases.
The symptoms of Lupus can be ethereal and vague, making the diagnosis difficult. The symptoms can vary so much that it may be misdiagnosed as many other illnesses. It often presents with mental symptoms and may be initially diagnosed as a mental disorder. Gastrointestinal inflammation from Lupus can cause eating problems that may be misdiagnosed as anorexia.
Although the disease most often presents as pain or profound fatigue, it can also cause cognitive and emotional problems. Some will experience forgetfulness and irritability. It is believed that the cause of these problems is vascular injury of the intracranial blood vessels.
Cognitive disturbances and memory loss are common problems in Lupus patients, but the disease can also present as a psychosis, major depressive disorder, or personality disorder, often of a histrionic type. In fact, it is believed that more than half of people with Lupus will present with mental problems.
For many, the first noticeable physical symptom is a butterfly-shaped rash on the face. This type of presentation has frequently been labeled as neuropsychiatric systemic lupus erythematosus NPSLE. Even so, the diagnosis of Lupus is often missed in patients with mental disorders. For example, in , researcher Neil Hopkinson tested three hundred hospitalized psychiatric patients for auto-antibodies in serum samples and found that one-in-one-hundred patients had undiagnosed Lupus.
As a result of these findings, Hopkinson recommends that tests for Lupus be done in every patient with a high erythrocyte sedimentation rate in psychiatric services. Drug induced Lupus, sometimes called DILE , is an autoimmune disorder similar to systemic Lupus, which is brought about by certain drugs.
It is caused by an autoimmune response producing symptoms similar to those of classic Lupus. Thus far, there are about 40 medications that can trigger this problem. The highest number of cases, however, are caused by hydralazine, brand name Apresoline, which is a vasodilator used to lower blood pressure; procainamide, brand name Pronestyl ; quinidine, brand name Quinaglute — both of which are used for cardiac arrhythmias; and isoniazid, brand name Laniazid or Nydrazid , which is an anti-tuberculosis medication.
Drug-induced Lupus symptoms include fever, elevated blood pressure, skin lesions, muscle and joint pains, and significant fatigue. Generally, the symptoms recede after discontinuing use of the drugs. Decreased levels of DHEA have been found in people with autoimmune disorders like Lupus and immune deficiency syndrome.
There is some evidence that DHEA can improve symptoms of these disorders. In a twelve-month, double-blind, placebo-controlled trial of women with mild or moderate Lupus, the effects of DHEA at a dose of mg daily reduced many symptoms of the disease. Nine out of ten are women.
Many patients will have joint pain. It produces a higher risk of developing lymphoma. It has a similar to presentation to multiple sclerosis and Lupus. All three disorders have an unpredictable course with waxing-and-waning of symptoms.
It most commonly presents as an atypical mood disorder, but can also cause, psychosis, dementia, somatization, dissociation, panic attacks, and personality changes.
Mental symptoms of candida. Physical symptoms of candida. Antibiotics have saved millions of lives. They are one of the reasons that we have increased our longevity. However, there is a correlation between the time line of the discovery and use of antibiotics and the rise of autoimmune disorders — the drugs that are saving lives may be causing long-term illnesses. Yeast occurs in all humans. It normally resides in the intestinal tract, mouth, throat, and genitals. In most people, the presence of the yeast has no symptoms.
However, antibiotics change the bacterial balance in the gut, causing an opportunistic infection of a yeast called candida albicans. Candida fungi are especially found in denture wearers.
The warmth and wetness between the denture and the roof of the mouth is a perfect habitat for the yeast. A Korean study found that in 38 people with antibiotic-associated diarrhea, the common yeast Candida was present in the stool cultures of three participants, while four had evidence of the bacterium costridium difficile C. Women with recurrent vaginal candidiasis were significantly more likely to suffer clinical depression, to be less satisfied with life, to have poorer self-esteem, and to perceive their lives as more stressful.
Additionally, women with recurrent vaginal candidiasis reported that their candidiasis seriously interferes with their sexual and emotional relationships. There is a connection between chronic yeast infections, candida, and mercury poisoning. It is thought that the body produces the yeast as a defense against excess heavy metals. The yeast cells absorb their own weight in mercury, which prevents the metals from entering the blood stream. The amount of mercury that candida cannot ingest is excreted as methyl mercury.
In some cases of obsessive compulsive disorder OCD , infection with the bacteria streptococcus may be a contributing cause. Researcher Susan Swedo replaced the blood plasma of 28 children who suffered from OCD and had elevated levels of streptococcus antibodies with healthy donor plasma. Within a month, the incidence of tics declined by half and their other OCD symptoms were reduced by 60 percent.
The pathogen has now been implicated in other disorders. Anorexia nervosa has emerged or has worsened after a case of strep throat. Dyskinesias are purposeless and involuntary movements. It is now known that streptococcus can trigger Sydenham's Chorea, a disorder that causes the arms and legs of those afflicted to jerk in a manner often likened to dancing.
Recently, the spectrum of post-streptococcal movement disorders has been expanded beyond chorea to include motor and vocal tics, dystonia, narcolepsy, and myoclonus. The prevalence of similar movement and emotional disorders in first-degree family relatives suggests that a genetic predisposition is important in disease development, in addition to an environmental event. Mental symptoms of Lyme disease. Physical symptoms in Lyme disease. Lyme disease is an infectious illness which often causes psychological symptoms.
The disease is transmitted to humans by an infected female Ixodes tick. Because this tick is smaller than the dog tick and because the bite is not painful, the tick is often unnoticed.
The infection requires that the tick feed for at least hours. The ticks are most commonly carried by deer and by the white-footed mouse, but other carriers have been found as well. The first recorded case of what is now known as Lyme disease was recorded in in Breslau, Germany, by Alfred Buchwald, a physician who described a skin disorder now known as acrodermatitis chronica atrophicans ACA. In , Doctor Arvid Afzelius published a paper describing a rash he suspected had been caused by the bite of an insect called the Ixodes tick.
In , the first case of Lyme disease in the United States was reported by Rudolph Scrimenti, who diagnosed and treated a patient who had been bitten by a tick while hunting grouse in Wisconsin. In , the first U. In , Allen Steere and his associates described the first clustering of a disease which was misdiagnosed as juvenile rheumatoid arthritis.
The malady is now called Lyme arthritis. While examining the ticks, Burgdorfer noticed a parasite in the body fluid of two ticks. As the result of his discovery, the bacteria have been named Borrelia burgdorferi. His research also confirmed that this bacteria was the cause of Lyme disease. In , Lyme disease researcher Paul Duray reported that Lyme disease bacteria infects multiple systems in the human body. In the same year, Burgdorfer was able to confirm that infected ticks could be found across the entire United States.
Today, Lyme disease is the most common insect-borne infection in the United States. In the last decades, it has been rapidly increasing in incidence. The disease often presents with a red, round, expanding rash within days or weeks after the bite. This is often followed by flu-like symptoms. After one or two months, there may be cardiac symptoms such as low heart rate and low blood pressure, myopericarditis inflammation of the wall of the heart , left ventricle dysfunction, and cardiomegaly enlarged heart.
Soon after, vision problems and nervous system symptoms begin. Early on, patients may begin to suffer frequent headaches. Conjunctivitis may also emerge. Other symptoms include profound fatigue, extreme sensitivity to sounds called auditory hyperacusis , sleep problems, and sensitivity to light photophobia. Psychological symptoms include agitation, irritability, emotional lability, paranoia, psychosis, dementia, bipolar disorder, anxiety, panic attacks, depression, anorexia, and obsessive-compulsive disorder.
Sometimes alterations in taste and smell occur. By six to ten months after the infection, many people will begin to suffer from arthritis in multiple joints. Neurological problems such as meningitis, encephalitis, or mild to severe marked mental symptoms occur. After two to eight years, the infection will cause chronic mental problems.
Because of this, patients with Lyme disease are often referred to mental health professionals before and after diagnosis. In a study, researcher Brain Fallon found that 40 percent of patients showed alterations in brain function.
Depression is very common, and in some studies 66 percent of sufferers show depressive symptoms. Impairments also occur in short-term memory, concentration, learning, and conceptual ability, suggesting problems in the frontal lobe. Cognitive problems include difficulty with word-finding, dyslexic-like errors when speaking or writing, and spatial disorientation. Interestingly, the prevalence of schizophrenia in the United States is highest in the urbanized Northeastern, Northwestern, and Great Lakes States.
These areas also have the highest presence of Lyme disease. In other parts of the world, the incidence of tick-borne encephalitis are also most prevalent in countries that also have the highest rates of schizophrenia, including Germany, Ireland, Finland, Croatia, and Norway.
Because the number of cases of the disease is rapidly increasing, Lyme disease should be included in the differential diagnosis of any mental health assessment. In its mechanism of infecting the body, Lyme disease is similar to syphilis, meaning it can cause damage over several decades.
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